Table 1.

The characteristics (mechanism of action and indications) of the antipsychotics reviewed.

Name od Drug	Aripiprazole	Brexpiprazole	Cariprazine	Lurasidone	Asenapine	Lumateperone	Pimavanserin
Mechanism of action	D2 partial agonist 5-HT1A partial agonist 5-HT2A antagonist	D2/D3 partial agonist 5-HT1A partial agonist 5-HT2A antagonist α1B/2C antagonist low affinity for H1 and M1 receptors	D2/D3 partial agonist 5-HT1A partial agonist low affinity for H1 and 5-HT2A receptors lack of affinity for M receptors	D2, 5-HT2A and 5-HT7 antagonist 5-HT1A partial agonist an affinity for adrenergic receptors–higher for α2C and slightly lower for α1 and α2A very low affinity for D1, 5-HT2C, H1 and M1 receptors	D2, 5-HT2A, 5-HT2C and 5-HT7 antagonist an affinity for adrenergic receptors –α1 and α2 lack of affinity for M receptors	full postsynaptic D2 antagonist D2 partial presynaptic agonist 5-HT2A antagonist D1 agonist SERT inhibitor	5-HT2A and 5-HT2C inverse agonist lack of affinity for DA receptors
Indications	schizophrenia acute mania unipolar depression (adjunct)	schizophrenia unipolar depression (adjunct)	schizophrenia acute mania	schizophrenia depressive symptoms in BD (monotherapy and adjunct)	schizophrenia BD (acute mixed and manic episodes)	schizophrenia	Parkinson’s disease psychosis