Table 1.
Summary of FABP isoforms in relation to psoriasis and their serum concentrations.
| FABP Isoform |
Name and Origin | Investigated in Serum in Psoriatics So Far |
Key Observation |
|---|---|---|---|
| FABP 1 (L-FABP) |
liver | Yes [21] | ↑ |
| FABP 2 (I-FABP) |
intestinal | Yes [30] | ↑ |
| FABP 3 (H-FABP) |
muscle and heart | Yes [20,34] | ~ |
| FABP 4 (A-FABP) |
adipocyte | Yes [20,34] | ↑ [20] /~ [34] |
| FABP 5 (E-FABP) |
epidermal (psoriasis-associated) |
Yes [43,44] | ↑/~ |
| FABP 6 (IL-FABP) |
ileal | No | - |
| FABP 7 (B-FABP) |
brain | Yes [58] | ↑ |
| FABP 8 (M-FABP) |
myelin (peripheral myelin protein 2) |
Yes [Author’s own investigation, yet to be published] | below detection level |
| FABP 9 (T-FABP) |
testis | No | - |
| FABP 12 | presence shown in human retinoblastoma cell lines, rodent retina, and testis | No | - |
↑ means elevated serum concentration, ↓ means decreased serum concentration, ~ means similar serum concentration compared to subjects without dermatoses.