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Importance of barrier function in preventing obesity. Diverse symbiotic species of bacteria protect the digestive tract by crowding out pathogens as well as maintaining the mucus barrier and promoting immune tolerance by dendritic sampling. Pathogens, antibiotics, and loss of the mucus layer degrades the integrity of the epithelial barrier via lowered MyD88 and immune recruitment creates sustained inflammation that may promote obesity [115,117]. Created in BioRender.com.
