Table 2.
Adjusted values of the pooled effect sizes for the absence of publication bias (Duval and Tweedie’s Trim and Fill).
| Outcomes | Number of Studies | Number of Patients | Pooled Effect Observed (95% CI) | p-Value | I2 (%) | Model Used | Studies Trimmed | Pooled Effect Adjusted (95% CI) |
|---|---|---|---|---|---|---|---|---|
| Histological improvement to normal or CIN 1 | 7 | 729 | RR: 0.779 (0.697 to 0.967) | 0.024 | 63.612 | Random | 3 | RR: 0.692 (0.553 to 0.866) |
| Vaccine Efficacy for complete resolution | 7 | 675 | VE: 23.6% (12.4% to 33.4%) | <0.001 | 56.516 | Random | 2 | VE: 18.7% (4.2% to 30.8%) |
| DNA clearance | 4 | 386 | RR: 0.768 (0.667 to 0.885) | <0.001 | 0 | Fixed | 2 | RR: 0.717 (0.637 to 0.801) |
| HPV-T cell response after vaccination | 4 | 357 | OR: 3.381 (1.245 to 9.182) | 0.017 | 0 | Fixed | 2 | OR: 2.371 (0.857 to 6.558) |