Figure 2.

Factors that can impact the scenario of the interplay between periprostatic adipose tissue (PPAT) and PCa cells: Genetic factors, such as ethnicity, could modify the effect of PPAT on cancer cells, through different cholesterol and FA metabolism, mediated by the gene fusion status. Obesity induces increased FA release from adipocytes, increased production of pro-tumor adipokines, and decreased production of anti-tumor adipokines. Obesity is also associated with increased estrogen synthesis in adipose tissue. Diet, through FA and POPs intake, is also able to modify the effect of PPAT on cancer cells. Dietary intake plays a key role in FA composition of PPAT, and therefore impacts the balance between pro-tumor and anti-tumor FA.