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. 2022 Sep 14;23(18):10697. doi: 10.3390/ijms231810697

Figure 2.

Figure 2

Chronic cold exposure promotes inflammatory pathways in lung tissue. (A) Toll-like receptor 4 (TLR4) mRNA expression. (B) Myeloid differentiation main response 88 (MyD88) mRNA expression. (C) Nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) mRNA expression. (D) High mobility group box 1 (HMGB1) mRNA expression. (E) Caspase1 mRNA expression. (F) IL-1β mRNA expression. (G) TLR4 protein expression. (H) MyD88 protein expression. (I) NLRP3 protein expression. (J) HMGB1 protein expression. (K) Mature-IL-1β protein expression. (L) Heat map of protein expression levels. Data are expressed as the mean ± SEM, n = 6, * p < 0.05.