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. 2022 Sep 3;14(9):1860. doi: 10.3390/pharmaceutics14091860

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic diagram showing the generation of redox-sensitive micelles made up of polyphosphoesters (PPEs): (A) mPEG₄₅-b-P(DssEEP₁₂-co-EEP₆) and mPEG₄₅-b-P(DssEEP₁₅-co-EEP₂₀). Note: N2-(2-(dodecyldisulfanyl)ethoxy)-1,3,2-dioxaphospholane 2-oxide (DssEEP). (B) Methoxy polyethylene glycol (mPEG) loaded with doxorubicin (DOX) is released in the presence of a GSH-rich milieu in the tumor microenvironment. Multidrug resistance (MDR), glutathione (GSH). Reproduced with permission from [64]. Copyright © 2015, American Chemical Society.