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. 2022 Sep 3;14(9):1860. doi: 10.3390/pharmaceutics14091860

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Chemical structures and schematic diagrams of PMs and respective drug candidates in the clinical trials, polymers used in the preparation (subscript represents molecular weights in Daltons) and drug molecule names are presented: (A) Genexol-PM block copolymer of poly(ethylene glycol)₂₀₀₀-b-poly(D,L-lactide)₁₇₅₀ and paclitaxel (PTX); (B) NK105 block copolymer of PEG₁₂₀₀₀-b-poly (4-phenyl-1-butanoate-L-aspartamide)₈₀₀₀ and paclitaxel (PTX); (C) Nanoxel-PM block copolymer of poly(ethylene glycol)₂₀₀₀-b-poly(Lactide)₁₇₆₅ and docetaxel; (D) Docecal XR-17 (N-all-trans retinoyl cysteine methyl ester sodium salt and N-13-cis retinoyl cysteine methyl ester sodium salt) and docetaxel; (E) NK012 block copolymer of poly(ethylene glycol)₁₂₀₀₀-b-poly(l-glutamic acid) and docetaxel modified and reprinted from [104] with permission from Elsevier, © 2022 Published by Elsevier B.V. on behalf of the Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Chemical structures and schematic diagrams of PMs and respective drug candidates in the clinical trials, polymers used in the preparation (subscript represents molecular weights in Daltons) and drug molecule names are presented: (A) Genexol-PM block copolymer of poly(ethylene glycol)₂₀₀₀-b-poly(D,L-lactide)₁₇₅₀ and paclitaxel (PTX); (B) NK105 block copolymer of PEG₁₂₀₀₀-b-poly (4-phenyl-1-butanoate-L-aspartamide)₈₀₀₀ and paclitaxel (PTX); (C) Nanoxel-PM block copolymer of poly(ethylene glycol)₂₀₀₀-b-poly(Lactide)₁₇₆₅ and docetaxel; (D) Docecal XR-17 (N-all-trans retinoyl cysteine methyl ester sodium salt and N-13-cis retinoyl cysteine methyl ester sodium salt) and docetaxel; (E) NK012 block copolymer of poly(ethylene glycol)₁₂₀₀₀-b-poly(l-glutamic acid) and docetaxel modified and reprinted from [104] with permission from Elsevier, © 2022 Published by Elsevier B.V. on behalf of the Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.