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. 2022 Sep 3;14(9):1860. doi: 10.3390/pharmaceutics14091860

Table 5.

Unit operations and the critical process parameters for the preparation of PMs.

S.No. Unit Operation Process Parameter
1 Polymer dissolution Process Temperature
Stirring speed
Stirring Time
2 Preparation of micelles Process Temperature
Homogenization Speed
Homogenization Time
3 Extrusion process Process Temperature
Number of Cycles
Membrane Pore Size
Pump Speed
4 Dia-filtration (Removal of ions) Conductivity of Filtrate
Process Temperature
Pump Speed
5 Drug Loading Process Temperature
Stirring Speed
Incubation Time
6 Filtration Filter Flushes
Filter Integrity
Filtration Time
Filtration Pressure