Figure 7.

Schematic summary of LTX-315 peptide interactions with lipid membranes and relevant mechanistic factors. The two main tested parameters were membrane surface charge and nanoarchitecture. In general, LTX-315 preferentially disrupts negatively charged membranes and demonstrates enhanced attachment to curved membranes over planar membranes. It should be noted that peptide attachment is a necessary but insufficient step for triggering membrane disruption, which was strongly related to the lipid composition.