Table 2.
Summary of aberrant expression of miRNA in human gestational disorders.
| Disorder Name | MiRNAs (Reference) | ||
|---|---|---|---|
| Pre-eclampsia (PE) |
Up-regulated | proliferation ↓ | miR-155 [107], miR-20a [132], miR-16 [135], miR-675 [136], miR-142-3p [138], miR-200p-3b [140], miR-137 [141], miR-146a [143] |
| migration ↓ | miR-155 [107], miR-431 [116], miR-20b [133], miR-16 [135], miR-125b [139], miR-200p-3b [140], miR-137 [141], miR-146a [143] | ||
| invasion ↓ | miR-431 [116], miR-30a-3p [117], miR-20a [132], miR-20b [133], miR-141 [137], miR-142-3p [138], miR-125b [139], miR-146a [143], miR-517a/b [145], miR-517c [145] | ||
| apoptosis ↑ | miR-30a-3p [117], miR-29b [134], miR-16 [135], miR-200p-3b [140] | ||
| differentiation ↓ | miR-17~92 clusters [146], miR-106a~363 clusters [146] | ||
| other/targets ↓ | miR-17 [68], miR-206 [129], miR-210 [131], miR-202-3p [142], miR-155 [144] | ||
| in exosomes | miR-222-3p [152], miR-486-1-5p [153], miR-486-2-5p [153], miR-155 [154], miR-136 [155], miR-494 [155], miR-495 [155] | ||
| Down-regulated | proliferation ↑ | miR-378a-5p [101], miR-376c [147], miR-335 [149], miR-126 [150] | |
| migration ↑ | miR-378a-5p [101], miR-3935 [124], miR-376c [147], miR-126 [150], | ||
| invasion ↑ | miR-378a-5p [101], miR-3935 [124] | ||
| apoptosis ↓ | miR-335 [149], miR-125a [151] | ||
| differentiation ↑ | miR-126 [150] | ||
| other/targets ↑ | miR-195 [148] | ||
| in exosomes | miR-153-3p [152], miR-653-5p [152], miR-325 [152] | ||
| Fetal Growth Restriction (FGR) |
Up-regulated | oxidative stress ↓ | miR-199a-5p [161] |
| other/targets ↓ | miR-424 [162], miR-519a [163], miR-1323 [164], miR-516b [164], miR-515-5p [164], miR-520h [164], miR-519d [164], miR-526b [164] | ||
| Down-regulated | other/targets ↑ | miR-518b [163], miR-16 [165], miR-21 [165] | |
| Gestational Diabetes Mellitus (GDM) |
Up-regulated | other/targets ↓ | miR-98 [166], miR-518d [167], miR-144 [168] |
| in exosomes | miR-122-5p [26], miR-132-3p [26], miR-1323 [26], miR-136-5p [26], miR-182-3p [26], miR-210-3p [26], miR-29a-3p [26], miR-29b-3p [26], miR-342-3p [26], miR-520h [26], miR-330-3p [169] |
||
| Down-regulated | proliferation ↑ | miR-296 [170], miR-96 [171], miR-137 [172] | |
| migration ↑ | miR-296 [170] | ||
| invasion ↑ | miR-296 [170] | ||
| in exosomes | miR-125b [168], miR-516-5p [173], miR-517-3p [173], miR-518-5p [173], miR-222-3p [173], miR-16-5p [173] | ||
| Early Recurrent Miscarriage | Up-regulated | apoptosis ↑ | miR-365 [174], miR-149 [175] |
| other/targets ↓ | miR-4497 [176] | ||
| Down-regulated | proliferation ↑ | miR-155-5p [177] | |
| apoptosis ↓ | miR-155-5p [177] | ||
| Preterm Birth (PTB) |
Down-regulated | other/targets ↑ | miR-338 [178], miR-29b-3p [179] |
| Small-for-Gestational-Age (SGA) | Down-regulated | other/targets ↑ | miR-21 [165], miR-16 [165] |