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. 2022 Sep 13;23(18):10635. doi: 10.3390/ijms231810635

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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ROC analysis—the combination of 7 clinical characteristics (maternal age and BMI at early stages of gestation, an infertility treatment by assisted reproductive technology, history of miscarriage, the presence of trombophilic gene mutations, positive first-trimester screening for PE and/or FGR by FMF algorithm, and a family history of diabetes mellitus in first-degree relatives) and 3 dysregulated microRNA biomarkers (miR-20a-5p, miR-20b-5p, and miR-195-5p). At a 10.0% FPR, 89.47% pregnancies destinated to develop GDM requiring a combination of diet and administration of appropriate therapy were identified during the first trimester of gestation. This represents 18 out of 20 pregnancies correctly predicted to develop GDM and 8 out of 80 normal pregnancies predicted false positively to develop GDM.