Table 1.

OnabotulinumtoxinA dosing in chronic migraine according to protocol PRREMPT [24].

Area of Injection	Recommended Dose
Frontalis Corrugator Procerus Occipitalis Temporalis Trapezius Cervical paraspinal muscle group	20 units (4 sites) 10 units (2 sites) 5 units (1 site) 30 units (6 sites) + 10 units in 2 sites (follow the pain areas—optional injections) 40 units (8 sites) + 10 units in 2 sites (follow the pain areas—optional injections) 30 units (6 sites) + 20 units in 4 sites (follow the pain areas—optional injections) 20 units (4 sites) Summary: 155–195 units