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. 2022 Sep 16;14(9):2053. doi: 10.3390/v14092053

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Patterns of blockade antibody seroconversion following infection with genogroup II human noroviruses. (Panel A): Univariate scatter plot of the fold increase in blockade antibody response between pre- and post-genogroup II norovirus infections; children color-coded by seroconverted genotype(s) identified by blockade Ab assay; dashed line indicates a ≥4-fold increase. X-axis is VLP used to test sera. Seroconversion color-coding: none (•), GII.4 (•), GII.12 (•), GII.4 and GII.12 (•) and GII.4 plus any other genogroup II genotype (•) (n = 26). Marker: one child. Line and error bars: geometric mean and 95% confidence intervals. Spearman’s correlation analysis of the fold increase in blockade antibody responses between GII.4 Sydney and GII.12 (Panel B) and between GII.4 Sydney and a closely related variant, GII.4 Den Haag (Panel C) among samples with 4-fold increase to one VLP. Dashed lines: 4-fold increase.