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. 2022 Sep 7;14(9):1894. doi: 10.3390/pharmaceutics14091894

Figure 6.

Figure 6

KVA-D88 loaded nanoparticles alleviate alcohol-induced liver injury and inflammation after systemic administration into mice. (A) Representative microscopic pictures of IHC staining for PDE4B. PDE4B expression was upregulated in mice liver by alcohol diet. Scale bars (120×), 100 μm. (B) Representative microscopic pictures of H&E staining of mice liver tissue. Scale bars (20×), 200 μm. (C,D) Mice plasma AST and ALT levels. (E,F) Mice hepatic mRNA expression level of TNF-α and IL-1β. Results are presented as the mean ± SD (n = 3). * p < 0.05, ** p < 0.01 and *** p < 0.005.