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. 2022 Sep 7;14(9):1891. doi: 10.3390/pharmaceutics14091891

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Stability analysis of the mitotane content of albumin-stabilized mitotane (BSA-MT) and liposomal mitotane (DOPC-MT) under different storage conditions. Aliquots of the samples were stored at 4–8 °C or 20–24 °C for 6 months (183 days) and analyzed for their mitotane content. (A) Mitotane content given in % of the initial drug content. (B) Drug retention of DOPC-MT. A value of 100% indicates no change in drug-to-lipid ratio and thus no drug leakage from liposomes. Data are expressed as mean ± SD, n = 3.