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. 2022 Sep 7;14(9):1891. doi: 10.3390/pharmaceutics14091891

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Therapeutic stability analysis of (A) albumin-stabilized mitotane (BSA-MT) and (B) liposomal mitotane (DOPC-MT) under different storage conditions. Cell viability of NCI-H295R cells was analyzed by the CellTiter-Glo^® luminescent cell viability assay 24 h after treatment with freshly prepared particles and particles stored for 3 and 6 months at 4–8 °C and 20–24 °C, respectively. Significant differences were evaluated via one-way ANOVA and Dunnett’s post-hoc test (* p < 0.05, further differences were not significant). Data are expressed as mean ± SD, n = 3.