Table 3.
Detection of other viruses, included in the review, in OLP patients.
| Reference (First Author + Year) |
Detection of EBV in Specimens of Oral Lichen Planus (%) | Detection of HSV1 in Specimens of Oral Lichen Planus (%) | Detection of HHV7 in Specimens of Oral Lichen Planus (%) | Technique | Clinical Features | Malignant Transformation |
|---|---|---|---|---|---|---|
| Cox 1993 [28] |
2/4 (50) | SBH | ||||
| Pedersen 1996 [54] |
NA (serum analysis) |
OD | ||||
| Cruz 1997 [55] |
1/2 (50) | PCR, SBH | ||||
| Sand 2002 [13] |
6/23 (26) | nPCR | 2 atrophic, 3 reticular, 1 unspecified OLP type (6/23 EBV+) | |||
| ÓFlatharta 2003 [35] |
2/26 (7.69) | 0/26 (0) | 3/26 (11.5) | PCR, SBH | ||
| Sahebjamee 2007 [56] |
0/22 (0) | PCR | ||||
| Kis 2009 [57] |
54/116 (46.5) | nPCR, IHC | 26/57 non- atrophic/erosive OLP EBV+ (57/116); 28/59 atrophic/erosive -OLP EBV+ (59/116) | |||
| Yildirim 2011 [12] |
23/65 (35.3) | 6/65 (9.2) | ABC | |||
| Adtani 2015 [58] |
NA (serum analysis) |
EI | ||||
| Vieira Rda 2016 [59] |
15/24 (62.5) | nPCR | 9/11 were atrophic/erosive lesions EBV+ (11/24); 6/13 were non-atrophic/erosive lesions EBV+ (13/24) | |||
| Danielsson 2018 [60] |
0/25 (0) | ISH, IHC | ||||
| Raybaud 2018 [61] |
73/99 (74) | ISH, PCR | 19/33 were reticular white lesions EBV+ (33/99); 55/66 erosive/ulcerative lesions with or without reticular lesions were EBV+ (66/99) | |||
| Shariati 2018 [62] |
6/38 (15.8) | PCR |
SBH = Southern blot hybridization; PCR = polymerase chain reaction (n = nested); NAH = nucleic acid hybridization; IHC = immunohistochemistry; OD = optometric density; ABC = avidin-biotin-peroxidase complex; EI = enzyme immunoassay; NA = not available; ISH = in situ hybridization; WBH = Western blot hybridization.