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Cytotoxic T cells played an important role in immune responses activated by Bio-MnO2 NPs plus radiation in vivo. (a) Schematic illustration of the experiment in vivo. (b) Growth curve of tumor volume after different treatments: IR + Bio-MnO2 NPs, IR + Bio-MnO2 NPs + Anti-CD8. (c) Tumor growth curve of each mouse. (d) Representative images of tumors. (e) Flow cytometry analysis of cytotoxic T cells in spleen and tumor tissues. ***, p < 0.001; ****, p < 0.0001.
