Figure 6.
Significant quantitative trait loci (QTL) associated with lesion frequency and microglial/macrophage reactivity following Theiler’s murine encephalomyelitis virus infection. (A) QTL analysis using gQTL revealed a region on mouse chromosome 13 which was significantly associated with lesion frequency in hippocampal adjacent regions at 4 dpi. (B) QTL analyses revealed a statistically significant region on chromosome 6 associated with microglial/macrophage reactivity at 4 dpi. (C) The association between the single nucleotide polymorphism (SNP) UNC22144316 on chromosome 13 and lesion frequency at 4 dpi was statistically significant (p = 6.58 × 10−81). Within that QTL interval were four genes of interest: Gm26043, Lyst, Gm30836, and Nid. The SNP JAX006033313 on chromosome 6 was significantly associated (p = 9.96× 10−79) with the level of microglial/macrophage reactivity at 4 dpi. One predicted gene, Gm24985, within this interval was just adjacent to another gene of interest: Tmem106b.