Table 2.

Complications in the included studies.

First author Year	No. of participants	Biopsy-related death	Respiratory failure	Cardiac complication	Bleeding	Other major complications	Pneumothorax	Infection	Other minor complications
Arabi 2007 [12]	14	0	Unknown	Unknown	0	Unknown	0	Unknown	Unknown
Baumann2008 [13]	27	0	Unknown	Unknown	1	1∗	9	2a	3∗∗
Charbonney 2009 [14]	19	Unknown	Unknown	Unknown	2	1∗	2	Unknown	Unknown
Cho 2006 [15]	53	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	16∗∗
Donaldson 2016 [16]	30	0	4	0	0	Unknown	4	Unknown	Unknown
Depuydt 2013 [17]	60	0	2	0	4	Unknown	3	Unknown	5∗∗
Gerard 2018 [18]	51	0	0	1	0	Unknown	2	Unknown	3∗∗
Kao 2015 [19]	101	0	Unknown	2	1	Unknown	Unknown	Unknown	11c
Lim 2007 [20]	36	0	Unknown	5	Unknown	Unknown	Unknown	Unknown	15∗∗
Ortiz 2019 [21]	15	0	Unknown	Unknown	1	Unknown	Unknown	Unknown	3∗∗
Papazian 1998 [22]	36	0	0	0	1	Unknown	1	Unknown	5∗∗
Papazian 2007 [23]	100	0	0	0	1	Unknown	2	0	8∗∗
Soh 2005 [24]	32	0	Unknown	Unknown	Unknown	Unknown	Unknown	2b	11d

∗Persistent air leak that required surgery.

∗∗Persistent air leak that did not require surgery.

^aWound infection (n = 2).

^bWound infection (n = 1) and empyema (n = 1).

^cPersistent air leak that did not require surgery (n = 8) and subcutaneous emphysema (n = 3).

^dPersistent air leak that did not require surgery (n = 9) and bronchopleural fistula (n = 2).