Table 2.

Overview of summarized findings of immune cell distribution related to inner ear morphology and developmental stage in non-syndromic inner ear tissue.

Antibody	Overview
IBA1	• Between GW9 and GW17 Macrophages/Monocytes found in the mesenchyme and connective tissue with an accumulation around spiral ganglia • First infiltration at GW13 into spiral ganglion • Between GW9 and GW17 no direct infiltration of macrophages and monocytes into the Organ of Corti • Start of GW13 few macrophages observed in the spiral ligament near the fibrocytes with migration to stria vascularis region • In vestibulum macrophages and monocytes found in mesenchyme and connective tissue
CD163	• Mainly in the mesenchymal and connective tissue of cochlea and vestibulum
CD68	• Distinct macrophage population during all the stages examined in the mesenchyme and connective tissue of cochlea and vestibulum • At GW16 single cells are present at the basilar membrane
CD45	• Single cells with CD45 expression in the mesenchyme of cochlea and vestibulum. • At GW18 one CD45 positive cell in the Reissner’s membrane
CX3CL1	• At GW9 expression in the mesenchymal tissue of cochlea • At GW10 diffuse and weak expression in the spiral ganglion tissue