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. 2022 Sep 9;13:953151. doi: 10.3389/fimmu.2022.953151

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Copyright © 2022 Raus, Lopez-Scarim, Luthy and Billerbeck

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD4+ iNKT cells with a mixed type 1 and type 2 signature are preferentially induced during acute infection. Hepatic iNKT cell subsets (n=4-8 mice per time point) were analyzed by flow cytometry at different stages of NrHV infection. (A) FACS plots showing T-bet and GATA-3 expression in CD4+ and CD4- subsets at day 7 pi. (B) Total numbers of GATA-3⁺Tbet⁺ and GATA-3^-Tbet^+/- CD4+ (left graph) and CD4- (right graph) iNKT cell subsets in the liver at multiple stages of infection and controls. (C) CD69 expression on GATA-3⁺Tbet⁺ and GATA-3^-Tbet^+/- subsets of CD4+ (upper graphs) and CD4- (lower graphs) iNKT cells. (D) FACS plots showing CD69 expression levels on iNKT cell subsets. (E) Ki67+ expression in GATA-3⁺Tbet⁺ and GATA-3^-Tbet^+/- subsets of CD4+ (blue) and CD4- (orange) iNKT cells. Unpaired t test and one-way ANOVA: *p< 0.5, **p<0.01, ***p<0.001.