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. 2022 Jul 25;71(10):2123–2135. doi: 10.2337/db21-1018

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© 2022 by the American Diabetes Association

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The phosphorylation of AKT^Ser473 is mTORC2 dependent and cell autonomous. Representative images of Western blot analysis for insulin signaling in primary hepatocytes isolated from control and Rictor^ΔLiver mice (A). Quantitative data of pIRS1^Tyr612/IRS1 (B), pAKT^Ser473/AKT (C), pAKT^Thr308/AKT (D), AKT^total (E), pGSK3α/β^Ser21/9/GSK3 (F), pFOXO1^Thr24/FOXO1 (G), and pPRAS40^Thr246/PRAS40 (H). All data are represented as mean ± SEM in 6- to 8-week-old mice. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001, using two-way ANOVA. Veh, vehicle.