Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Rational structural modification of the reported pyridopyrazinone-based derivatives as PDE5 inhibitors. The orientation of the terminal groups is modified structurally. In the reported inhibitors, pyridopyrazinone scaffold is designed to be the central motif. In the tested compounds, the pyridopyrazinone ring is functioning as one of binding motifs.
