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. 2022 Sep 15;14(9):1954. doi: 10.3390/pharmaceutics14091954

Table 3.

The experimental and predicted PDE5 IC50 values of the test set (series B, D, E and G) in nM.

9 IC50 (nM) Compound IC50 (nM)
Exp Pred Exp Pred
6a 59.13 51.38 8i 137.31 71.38
6b 67.91 70.36 8j ND 137.24
6c 47.00 7.83 9a 32.20 39.33
8a 93.83 27.49 9b 30.42 99.61
8b 44.63 26.75 9c 41.41 58.31
8c 89.01 38.97 9d 32.34 −4.21
8d 101.32 81.56 9e 29.40 66.24
8e ND 66.27 11a 26.33 49.54
8f 21.01 66.27 11b 18.13 68.52
8g ND 66.27 11c 31.03 6.00
8h ND 141.84

Exp, experimental; Pred, predicted; ND, not determined.