Table 1.
Classification of STSs from Basidiomycota.
| Type of Cyclization |
Precursor | Metabolite | Producer | Biochemically Verified Enzyme | |
|---|---|---|---|---|---|
| Clade I | C1,10 | FPP | Intermedeol (1) | Macrolepiota albuminosa | STC4 |
| Germacrene D-4-ol (2) | Macrolepiota albumi-nosa | STC15 | |||
| Germacrene A (4) | Coprinopsis cinerea | Cop1, Cop2 | |||
| T-Cadinol (8) | Taiwanofungus camphoratus | AcTPS5 | |||
| α-Muurolene (5) | Omphalotus olearius | Omp1, Omp3 | |||
| Cerrena unicolor | Cun0759 | ||||
| Coprinopsis cinerea | Cop3 | ||||
| Rhodonia placenta | PpSTS01 | ||||
| Cyclocybe aegerita | Agr3 | ||||
| Ganoderma sinense | GS14272 | ||||
| Ganoderma lucidum | GL26009 | ||||
| Phanerodontia chrysosporium | PcSTS01 | ||||
| Clitopilus pseudo-pinsitus | CpSTS3, CpSTS5 | ||||
| α-Cadinol (30) |
Lignosus rhinoceros
Ganoderma sinense |
GME3634
GS02363 |
|||
| Torreyol (31) | Lignosus rhinocerus | GME3638 | |||
| δ-Cadinol (20) | Cerrena unicolor | Cun7050 | |||
| Boreostereum vibrans | BvCS | ||||
| Coniophora puteana | Copu5, Copu9 | ||||
| Clitopilus pseudo-pinsitus | CpSTS3 | ||||
| α-Copaene (35) | Cerrena unicolor | Cun3574 | |||
| γ-Cadinene (3) | Cerrena unicolor | Cun3817 | |||
| Rhodonia placenta | PpSTS03 | ||||
| Germacrene D (36) | Cerrena unicolor | Cun0773 | |||
| δ-Cadinene (6) | Rhodonia placenta | PpSTS01 | |||
| Phanerodontia chrysosporium | PcSTS01 | ||||
| Stereum hirsutum | ShSTS7 | ||||
| β-Elemene (21) | Rhodonia placenta | PpSTS01 | |||
| α-Cadinene (38) | Rhodonia placenta | PpSTS03 | |||
| α-Gurjunene (39) Viridiflorol (49) γ-Muurolene (26) |
Rhodonia placenta
Serendipita indica Ganoderma lucidum Phanerodontia chrysosporium |
PpSTS06
SiTPS GL26009 PcSTS01 |
|||
| Clade II | C1,10 | NPP | δ-Cadinene (6) | Coprinopsis cinerea | Cop4 |
| Cerrena unicolor | Cun3158 | ||||
| Rhodonia placenta | PpSTS10 | ||||
| Clitopilus pseudo-pinsitus | CpSTS2 | ||||
| Cyclocybe aegerita | Agr1, Agr4 | ||||
| Omphalotus olearius | Omp4 | ||||
|
Stereum hirsutum
Phanerodontia chrysosporium |
ShSTS10, ShSTS11
PcSTS02, PcSTS04 |
||||
| Cubebol (9) |
Taiwanofungus camphoratus
Coniophora puteana |
AcTPS9
Copu2, Copu3 |
|||
| 1-epi-Cubenol (47) | Stereum hirsutum | ShSTS8 | |||
| Zonarene (10) | Taiwanofungus camphoratus | AcTPS4 | |||
| Ledene (19) | Clitopilus pseudo-pinsitus | CpSTS13 | |||
| Virifloridol (18) | Clitopilus pseudo-pinsitus | CpSTS9, CpSTS12 | |||
| Viridiflorol (49) | Sphaerobolus stellatus | Sphst_47084 | |||
| Alloaromadendrene (16) | Clitopilus pseudo-pinsitus | CpSTS8 | |||
| 9-Alloaromadendrene (17) | Clitopilus pseudo-pinsitus | CpSTS11 | |||
| Aristolene (15) | Clitopilus pseudo-pinsitus | CpSTS16 | |||
| Viridiflorene (25) | Cyclocybe aegerita | Agr2, Agr5 | |||
| γ-Cadinene (3) | Omphalotus olearius | Omp5a, Omp5b | |||
| α-Cubebene (48) | Stereum hirsutum | ShSTS12 | |||
| β-Cubebene (34) | Cerrena unicolor | Cun3157 | |||
| Germacrene D (36) | Stereum hirsutum | ShSTS10 | |||
| β-Copaene (40) |
Coniophora puteana
Phanerodontia chrysosporium |
Copu2, Copu3
PcSTS02, PcSTS04 |
|||
| β-Gurjunene (27) Epicubenol (42) β-Farnesene (22) Cadina-1(6),4-diene (41) |
Galerina marginata
Phanerodontia chrysosporium Phanerodontia chrysosporium Phanerodontia chrysosporium |
Galma_104215
PcSTS03 PcSTS02, PcSTS04 PcSTS02, PcSTS04 |
|||
| Clade III | C1,11 | FPP | α-Humulene (24) | Hypholoma fasciculare | Hfas94a, Hfas94b |
| Δ6-Protoilludene (11) | Hypholoma lateritium | Hypsu1_138665 | |||
| Stereum hirsutum | ShSTS15, ShSTS16, ShSTS17, ShSTS18 | ||||
| Heterobasidion annosum | Hetan2_454193 | ||||
| Cyclocybe aegerita | Agr6, Agr7 | ||||
| Clitopilus pseudo-pinsitus | CpSTS4 | ||||
| Rhodonia placenta | PpSTS08 | ||||
| Omphalotus olearius | Omp6, Omp7 | ||||
| Armillaria gallica | Pro1 | ||||
| Dendrodontia bispora | Denbi1_659367 | ||||
| Aromadendrene (37) | Cerrena unicolor | Cun5155 | |||
| β-Caryophyllene (23) | Stereum hirsutum | ShSTS13 | |||
| Pentalenene (13) | Rhodonia placenta | PpSTS14 | |||
| Clitopilus pseudo-pinsitus | CpSTS6 | ||||
| Sterpurene (12) | Clitopilus pseudo-pinsitus | CpSTS1 | |||
| α-Farnesene (14) | Clitopilus pseudo-pinsitus | CpSTS7 | |||
| γ-Muurolene (26) | Cyclocybe aegerita | Agr8 | |||
| 1,3,4,5,6,7-Hexahydro-2,5,5-trimethyl-2H-2,4a-ethanonaphthalene (32) | Lignosus rhinocerus | GME9210 | |||
| 1-Napthalenol (33) | Lignosus rhinocerus | GME9210 | |||
| γ-Cadinene (3) | Ganoderma sinense | GsSTS43, GsSTS45b | |||
| Ganoderma lucidum | GISTS6 | ||||
| Clade IV | C1,6 | NPP | α-Cuprenene (7) |
Coprinopsis cinerea
Ganoderma sinense Fomitopsis pinicola |
Cop6
GS11330 Fompi1 |
| α-Barbatene (28) |
Omphalotus olearius
Phanerodontia chrysosporium |
Omp9
PcSTS06 |
|||
| β-Barbatene (43) | Phanerodontia chrysosporium | PcSTS06 | |||
| Stereum hirsutum | ShSTS1 | ||||
| α-Farnesene (14) | Stereum hirsutum | ShSTS3 | |||
| β-Farnesene (22) |
Stereum hirsutum
Clitopilus pseudo-pinsitus |
ShSTS3
CpSTS14 |
|||
| Hirsutene (46) | Stereum hirsutum | ShSTS4 | |||
| γ-Cadinene (3) |
Termitomyces
albuminosus |
STC9 | |||
| Stereum hirsutum | ShSTS5 | ||||
| Clitopilus pseudo-pinsitus | CpSTS18 | ||||
| β-Elemene (21) | Clitopilus pseudo-pinsitus | CpSTS14 | |||
| β-Caryophyllene (23) | Clitopilus pseudo-pinsitus | CpSTS17 | |||
| (E)-Dauca-4(11),8-diene (29) | Omphalotus olearius | Omp10 | |||
| δ-Cadinol (20) | Cerrena unicolor | Cun0716 | |||
| (E)-α-Bisabolene (44) | Phanerodontia chrysosporium | PcSTS08 | |||
| α-Santalene (45) | Phanerodontia chrysosporium | PcSTS11 | |||
| others | — | Coprinopsis cinerea | Cop5 | ||
| — | Clitopilus pseudo-pinsitus | CpSTS10 | |||
| — | Hypholoma fasciculare | Hfas255 | |||
| Unknown | Hypholoma fasciculare | Hfas344 | |||
| Unknown | Cyclocybe aegerita | Agr9 | |||
| — | Cyclocybe aegerita | Agr10, Agr11 | |||
| — | Omphalotus olearius | Omp8 | |||
| — | Cerrena unicolor | Cun5765, Cun6114, Cun7487, Cun0802 | |||
| Unable to identify | Cerrena unicolor | Cun9106 | |||
| — | Ganoderma sinense | GsSTS45a | |||
| Unknown | Sanghuangporus baumii | SbTps1 | |||
| Viridiflorol (49) | Dendrodontia bispora | Denbi1_816208 | |||
| Hirsutene (46) | Stereum hirsutum | HS-HMGS | |||
| Steccherinum ochraceum | A8411 |