Table 3.
Significant a modification effects of baseline parameters and general characteristics on the associations of BTX CE levels with decline in hematologic parameters.
| BTX Component | Decline in Hematologic Parameters | Associations (β (95% CI)) b in Different Subgroups | P interaction c | ||
|---|---|---|---|---|---|
| Stratified by baseline parameters d | Low | Medium | High | ||
| Benzene | Monocytes | 0.015 (0.001, 0.029) § | 0.004 (−0.010, 0.018) | 0.026 (−0.009, 0.061) | 0.008 |
| Toluene | Monocytes | 0.009 (−0.005, 0.023) | 1.98 × 10−4 (−0.015, 0.016) | 0.021 (−0.020, 0.062) | <0.001 |
| Xylene | Monocytes | 0.011 (−0.007, 0.029) | −0.006 (−0.024, 0.012) | 0.053 (0.004, 0.102) § | <0.001 |
| Toluene | RBC | −0.012 (−0.045, 0.021) | 0.016 (−0.023, 0.055) | 0.059 (0.006, 0.112) § | 0.027 |
| Xylene | RBC | −4.90 × 10−4 (−0.042, 0.041) | 2.96 × 10−4 (−0.047, 0.047) | 0.085 (0.028, 0.142) § | <0.001 |
| Toluene | Hemoglobin | −0.292 (−1.515, 0.931) | 0.201 (−0.779, 1.181) | 1.647 (0.120, 3.174) § | 0.012 |
| Toluene | Hematocrit | 0.153 (−0.186, 0.492) | 0.006 (−0.286, 0.298) | 0.555 (0.063, 1.047) § | 0.014 |
| Xylene | Hematocrit | 0.235 (−0.184, 0.654) | −0.030 (−0.387, 0.327) | 0.780 (0.247, 1.313) § | 0.001 |
| Stratified by sex | Female | Male | |||
| Xylene | Lymphocytes | 0.044 (−0.032, 0.120) | 0.061 (0.002, 0.120) § | 0.001 | |
| Toluene | RBC | −0.021 (−0.080, 0.038) | 0.018 (−0.007, 0.043) | 0.038 | |
| Xylene | RBC | −0.026 (−0.081, 0.029) | 0.032 (0.001, 0.063) § | 0.001 | |
| Xylene | Hemoglobin | −0.751 (−2.640, 1.138) | 1.003 (0.125, 1.881) § | 0.036 | |
| Benzene | Hematocrit | −0.347 (−0.917, 0.223) | 0.206 (0.022, 0.390) § | 0.033 | |
| Toluene | Hematocrit | −0.420 (−1.067, 0.227) | 0.271 (0.073, 0.469) § | 0.011 | |
| Xylene | Hematocrit | −0.249 (−0.870, 0.372) | 0.401 (0.150, 0.652) § | 0.033 | |
| Stratified by drinking status | Nondrinker | Drinker | |||
| Benzene | Neutrophils | 0.069 (−0.031, 0.169) | −0.044 (−0.152, 0.064) | 0.048 | |
| Benzene | Lymphocytes | 0.045 (−0.006, 0.096) | 0.025 (−0.030, 0.080) | 0.030 | |
| Toluene | Lymphocytes | 0.068 (0.013, 0.123) § | 0.026 (−0.033, 0.085) | 0.033 | |
| Stratified by BMI (kg/m2) | <24 | ≥24 | |||
| Benzene | Neutrophils | −0.017 (−0.111, 0.077) | 0.065 (−0.049, 0.179) | 0.012 | |
| Toluene | Neutrophils | −0.101 (−0.205, 0.003) | 0.070 (−0.050, 0.190) | 0.001 | |
| Toluene | Lymphocytes | 0.016 (−0.037, 0.069) | 0.086 (0.023, 0.149) § | 0.029 | |
| Xylene | Lymphocytes | 0.010 (−0.049, 0.069) | 0.093 (0.011, 0.175)§ | 0.023 | |
Note: Abbreviations: RBC, red blood cell. a This table only shows significant modification effects that had a Pinteraction lower than 0.05. b Generalized linear model with adjustment for age, sex, factory location, BMI, smoking status, pack-years of smoking, drinking status, and/or baseline hematologic parameters when appropriate. c Pinteraction was calculated by modeling an interaction term of each BTX component and each stratified variable in generalized linear models, with adjustment for age, sex, factory location, BMI, smoking status, pack-years of smoking, drinking status, and/or baseline hematologic parameters when appropriate. d Subjects were divided into three groups (low, medium, and high) according to the tertiles of the baseline hematologic parameters. § Ptrend < 0.05.