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. 2022 Aug 25;144(37):16930–16952. doi: 10.1021/jacs.2c05499

Figure 2.

Figure 2

Screening of the first-generation PROTACs in wild-type (WT) and G2019S LRRK2 MEFs. (A) Representative Western blots monitoring the total LRRK2, LRRK2-pSer935, Rab10-pThr73, total Rab10, and tubulin levels following the treatment of WT and G2019S MEFs with the indicated compounds at 33 nM, 1 μM, or dimethyl sulfoxide (DMSO) for 4 h. (B) Quantitative analysis of the relative LRRK2 protein and Rab10-pThr73 levels, which are presented as ratios of total LRRK2/tubulin or Rab10-pThr73/total Rab10, normalized to the DMSO-treated sample. Data were obtained from two biological independent experiments.