Table 3. Pharmacokinetic (PK) Parameters of XL01126 Following a Single Dose of XL01126 via IV, IP, and PO.
| plasma PK properties | CL (L/h/kg) | Vss (L/kg) | Tmax (h) | Cmax (ng/mL) | T1/2 (h) | AUClast (h ng/mL) | AUCinf (h ng/mL) | MRT (h) | F (%) |
|---|---|---|---|---|---|---|---|---|---|
| IVa (5 mg/kg) | 0.208 | 0.511 | 1.52 | 23 663 | 23 981 | 2.45 | |||
| IPb (30 mg/kg) | 0.25 | 7700 | 5.2 | 41 434 | 64 068 | 29.2 | |||
| POc (30 mg/kg) | 2 | 3620 | 21.9 | 21 337 | 109 271 | 15 |
a
Intravenous.
b
Intraperitoneal.
c
Peroral. CL, clearance; Vss, volume of distribution; Tmax, the time the compound takes to reach the maximum plasma concentration; Cmax, the maximum plasma concentration a compound reached after dosing; AUC, area under the curve; MRT, mean resident time; and F, bioavailability.