Table 3.
Adverse events following immunization (AEFIs) for the second dose. AEFIs: adverse events following immunization. * Fisher’s exact test, significantly higher (p < 0.05) than the first dose (Table 2). † Other local AEFIs include nasal mucus, sore throat, and others. ‡ Other systemic AEFIs include dizziness, palpitation, sweating, and others. Day 0 is defined as the day of immunization.
| Day 0 (n = 203) |
Day 1 (n = 179) |
Day 3 (n = 138) |
Day 7 (n = 130) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Any AEFI | 188 | (92.6%) * | 176 | (98.3%) * | 73 | (52.9%) * | 14 | (10.8%) | |
| Local | Injection-site pain | 165 | (81.3%) | 154 | (86.0%) | 46 | (33.3%) | 3 | (2.3%) |
| Localized warmth | 82 | (40.4%) * | 88 | (49.2%) * | 23 | (16.7%) * | 1 | (0.8%) | |
| Exanthema | 4 | (2.0%) | 3 | (1.7%) | 2 | (1.4%) | 1 | (0.8%) | |
| Erythema | 19 | (9.4%) * | 24 | (13.4%) * | 20 | (14.5%) * | 1 | (0.8%) | |
| Swelling | 26 | (12.8%) | 35 | (19.6%) | 18 | (13.0%) * | 0 | ||
| Itchiness | 12 | (5.9%) * | 12 | (6.7%) * | 28 | (20.3%) * | 5 | (3.8%) | |
| Red eye | 1 | (0.5%) | 1 | (0.6%) | 0 | 0 | |||
| Others † | 4 | (2.0%) | 5 | (2.8%) | 3 | (2.2%) | 2 | (1.5%) | |
| Systemic | Malaise | 105 | (51.7%) * | 134 | (74.9%) * | 17 | (12.3%) | 5 | (3.8%) |
| Fever | 108 | (53.2%) * | 157 | (87.7%) * | 8 | (5.8%) | 3 | (2.3%) | |
| Fatigue | 45 | (22.2%) * | 58 | (32.4%) * | 14 | (10.1%) * | 2 | (1.5%) | |
| Myalgia | 48 | (23.6%) | 69 | (38.5%) * | 9 | (6.5%) | 3 | (2.3%) | |
| Arthralgia | 37 | (18.2%) * | 80 | (44.7%) * | 4 | (2.9%) | 1 | (0.8%) | |
| Nausea/Vomiting | 7 | (3.4%) | 12 | (6.7%) | 3 | (2.2%) | 0 | ||
| Diarrhea | 3 | (1.5%) | 3 | (1.7%) | 1 | (0.7%) | 0 | ||
| Chills | 51 | (25.1%) * | 60 | (33.5%) * | 4 | (2.9%) | 0 | ||
| Headache | 59 | (29.1%) * | 97 | (54.2%) * | 32 | (23.2%) * | 5 | (3.8%) | |
| Rash | 1 | (0.5%) | 3 | (1.7%) | 1 | (0.7%) | 1 | (0.8%) | |
| Others ‡ | 4 | (2.0%) | 13 | (7.3%) | 4 | (2.9%) | 0 | ||
| Medical Care Sought | Doctor visit | 0 | 1 | (0.6%) | 1 | (0.7%) | 0 | ||
| Use of analgesics | 84 | (41.4%) * | 128 | (71.5%) * | 18 | (13.0%) * | 4 | (3.1%) | |