Table 4.
Adverse events following immunization (AEFIs) for the third dose. AEFIs: adverse events following immunization. † Fisher’s exact test, significantly higher (p < 0.05) than the first dose (Table 2). ‡ Other local AEFIs include sore neck, sore throat, and others. # Other systemic AEFIs include anorexia, hot flashes, mild chest pain, and others. Day 0 is defined as the day of immunization.
| Day 0 (n = 42) |
Day 1 (n = 38) |
Day 3 (n = 35) |
Day 7 (n = 27) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Any AEFI | 36 | (85.7%) | 36 | (94.7%) | 16 | (45.7%) | 3 | (11.1%) | |
| Local | Injection-site pain | 36 | (85.7%) | 36 | (94.7%) | 11 | (31.4%) | 1 | (3.7%) |
| Localized warmth | 15 | (35.7%) † | 20 | (52.6%) † | 4 | (11.4%) † | 0 | ||
| Exanthema | 0 | 0 | 0 | 0 | |||||
| Erythema | 0 | 1 | (2.6%) | 2 | (5.7%) | 0 | |||
| Swelling | 3 | (7.1%) | 4 | (10.5%) | 4 | (11.4%) | 0 | ||
| Itchiness | 0 | 0 | 4 | (11.4%) | 2 | (7.4%) | |||
| Red eye | 0 | 1 | (2.6%) | 0 | 0 | ||||
| Axillary swelling | 2 | (4.8%) | 5 | (13.2%) | 4 | (11.4%) | 1 | (3.7%) | |
| Others ‡ | 1 | (2.4%) | 1 | (2.6%) | 0 | 2 | (7.4%) | ||
| Systemic | Malaise | 17 | (40.5%) † | 30 | (78.9%) † | 5 | (14.3%) | 0 | |
| Fever | 12 | (28.6%) † | 31 | (81.6%) † | 1 | (2.9%) | 0 | ||
| Fatigue | 9 | (21.4%) † | 22 | (57.9%) † | 3 | (8.6%) | 0 | ||
| Myalgia | 6 | (14.3%) | 12 | (31.6%) | 2 | (5.7%) | 1 | (3.7%) | |
| Arthralgia | 9 | (21.4%) † | 14 | (36.8%) † | 1 | (2.9%) | 0 | ||
| Nausea/Vomiting | 1 | (2.4%) | 2 | (5.3%) | 0 | 0 | |||
| Diarrhea | 0 | 0 | 0 | 0 | |||||
| Chills | 7 | (16.7%) † | 12 | (31.6%) † | 0 | 0 | |||
| Headache | 5 | (11.9%) | 17 | (44.7%) † | 0 | 0 | |||
| Rash | 0 | 0 | 0 | 0 | |||||
| Others # | 2 | (4.8%) | 1 | (2.6%) | 0 | 0 | |||
| Medical Care Sought | Doctor visit | 0 | 1 | (2.6%) | 0 | 0 | |||
| Use of analgesics | 12 | (28.6%) | 21 | (55.3%) | 2 | (5.7%) | 0 | ||