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. 2022 Sep 9;10:981055. doi: 10.3389/fchem.2022.981055

FIGURE 4.

FIGURE 4

After the near-infrared fluorescent dye DiR and C6 loaded into zein-Casein NPs, the advantages of zein-Casein NPs on colon-specific accumulation and tissue penetration were observed. (A) Fluorescence images of mice at 3, 6, 12, and 24 h after oral administration of free DiR and DiR@NPs. (B) Histogram of fluorescence intensity in mice at 3, 6, 12, and 24 h after oral administration of free DiR and DiR@NPs (n = 3, Δ p < 0.05). (C) Fluorescence images of the gastrointestinal tract of mice at 3, 6, 12, and 24 h after oral administration of free DiR and DiR@NPs. (D) Fluorescence images of frozen sections after oral administration of free C6 and C6@NPs for 12 h, green fluorescence represented C6, and blue fluorescence represented the location of the cell nucleus (scale bar = 200 μm).