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. 2022 Sep 9;10:981055. doi: 10.3389/fchem.2022.981055

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Copyright © 2022 Xiao, Wu, Cheng, Ma, Luo, Chang, Zhang, Chen, Zou, You and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathological evaluation and inflammatory factor determination. (A) Histopathological evaluation by H&E and PAS staining for different groups. Scale bar = 100 μm. The levels of IL-6 (B) and TNF-α (C) in colon tissue of mice at day 10. ^* p < 0.05 (model group vs. control group), ^Δ p < 0.05 (model group vs. free ISL and ISL@NPs groups).