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. 2022 Sep 9;15:942548. doi: 10.3389/fnmol.2022.942548

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Copyright © 2022 Patel, Sakurai, Himmel and Cox.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pkd2 and IP₃R genetically interact in cold nociception, but not innocuous mechanosensation. (A) Cold plate analysis of Drosophila larvae mutant for either/both Pkd2¹ and IP₃R^ka901. We report %CT (left), CT duration in seconds (middle), CT magnitude (right). N_Average = 70. (B,C) Gentle touch assay of Drosophila larvae mutant for either/both Pkd2¹ and IP₃R^ka901. (B) Proportion of each touch score per trial for each genotype. (C) Average total touch scores for each larva per genotype. N_Average = 22. Statistics: Kruskal–Wallis with Benjamini, Krieger, and Yekutieli for multiple comparisons. (A–C) Genotypes include: w1118, Pkd2¹/+, and IP₃R^ka901/+, Pkd2¹/IP₃R^ka901. Significant differences indicated via asterisks, where *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.