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Summary of molecules required for cold nociceptive behaviors. Plasma membrane localized TRP channels (Turner et al., 2016) and GPCR (GABAB-R2) are required for cold-evoked behaviors. Gα q and Plc signaling is also required for cold nociception. ER localized IP3R and RyR channels are required for cold-evoked CT response. GABAB-R2, IP3R, and RyR are all required for cold-evoked Ca2+ increases. Created with BioRender.com.
