Table 1.

Candidate directional anchor genes for schizophrenia and bipolar along with their associated drug-repurposing candidates

Gene	Disorder	Protective direction	Repurposing candidates	Sensitivity analyses
PCCB	SZ	increased expression	biotin	high-confidence causal gene from TWAS (PIP > 0.8), further supported by MR
FADS1	BIP	increased expression	icosapent, linolenic acid	moderate-confidence causal gene from TWAS (PIP > 0.4, additionally supported by colocalization – PPH4 > 0.8), further supported by MR
GRIN2A	SZ	increased expression	N-acetylcysteine, glycine	high-confidence causal gene from TWAS (PIP > 0.8)
CACNA1C	SZ	increased expression	ibutilide	moderate-confidence causal gene from TWAS (PIP > 0.4, additionally supported by colocalization – PPH4 > 0.8)
RPS17	SZ	increased expression	artenimol	moderate-confidence causal gene from TWAS (PIP > 0.4, additionally supported by colocalization – PPH4 > 0.8)
FES	SZ	decreased expression	Fostamatinib, Lorlatinib	high-confidence causal gene from TWAS (PIP > 0.8)