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. 2022 Sep 5;14(9):1868. doi: 10.3390/pharmaceutics14091868

Figure 6.

Figure 6

Protective effect of betulin on alveolar bone and fibrous tissue lost with PG-LPS in a periodontitis-induced in vivo in vivo model. Methods of inducing periodontitis in vivo in vivo models are described in materials and methods Section 2.9. The images of the alveolar bone newly formed by betulin were taken through micro-CT (3 mm) (A). Confirmation of periodontal fibrous tissue protective effect through Goldner’s Masson Trichrome staining (B). The CEJ-ABC distance and BMD were quantified through VGStudio MAX 1.2.1 software by setting the red part as the quantitative area (C). Measurement of the thickness of periodontal fibrous tissue by setting the red part as the quantitative area (D). * p < 0.05 was considered significant differences between only PG-LPS treated groups. Each group (n = 3).