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Impact of oligonucleotide uptake in the liver versus immunostimulatory impact. A map of the most prevalent liver cell types is at upper left. Relative immunoreactivity to oligonucleotides via TLR3/7/8 and 9 is indicated at upper right. Cell uptake with oligonucleotides are indicated as unconjugated ASOs (middle left), LNP formulation siRNA (lower left) and GalNAc conjugated-ASO or siRNA (lower right). Stronger cellular accumulation is indicated by darker shading.
