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. 2022 Sep 7;20(9):570. doi: 10.3390/md20090570

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of Saq B₁ against the PI3K/AKT pathway in SW480 and SW620 cells. (A) The overall survival rate of patients with high or low PIK3CA expression was assessed via Kaplan–Meier survival analysis. (B,C) Western blot analysis was used to investigate the effects of Saq B₁ on PI3K, AKT, and p-AKT proteins. (D) The expression of p-AKT was observed by immunofluorescence staining. Representative images of each condition are shown; p-AKT (green) and DAPI (blue). Scale bars = 20 µm. The level of intracellular p-AKT decreased, which was consistent with Western blot results. * p < 0.05, ** p < 0.01, *** p < 0.001.

Effect of Saq B₁ against the PI3K/AKT pathway in SW480 and SW620 cells. (A) The overall survival rate of patients with high or low PIK3CA expression was assessed via Kaplan–Meier survival analysis. (B,C) Western blot analysis was used to investigate the effects of Saq B₁ on PI3K, AKT, and p-AKT proteins. (D) The expression of p-AKT was observed by immunofluorescence staining. Representative images of each condition are shown; p-AKT (green) and DAPI (blue). Scale bars = 20 µm. The level of intracellular p-AKT decreased, which was consistent with Western blot results. * p < 0.05, ** p < 0.01, *** p < 0.001.