Table 1.
IC50 of four angucyclines and doxorubicin in different cell lines at 48 h.
| Compounds | SW480 | SW620 | LoVo | HT-29 | QSG-7701 |
|---|---|---|---|---|---|
| IC50 (μmol/L) | |||||
| Moromycin B | 0.45 ± 0.06 | 0.34 ± 0.05 | 0.78 ± 0.02 | 0.82 ± 0.04 | 1.26 ± 0.15 |
| Saquayamycin B1 | 0.18 ± 0.01 | 0.26 ± 0.03 | 0.63 ± 0.07 | 0.84 ± 0.05 | 1.57 ± 0.12 |
| Saquayamycin B | 0.32 ± 0.03 | 0.42 ± 0.02 | 0.75 ± 0.03 | 0.89 ± 0.02 | 1.38 ± 0.14 |
| Landomycin N | >20 | >20 | >20 | >20 | >20 |
| Doxorubicin | 0.91 ± 0.08 | 1.06 ± 0.11 | 0.83 ± 0.12 | 1.02 ± 0.10 | 1.33 ± 0.03 |
Cytotoxicity of four angucyclines and doxorubicin on SW480, SW620, LoVo, HT-29, and QSG-7701 cells were examined by MTT assay. Cells were exposed to varying concentrations of compounds for 48 h and the IC50 values were then calculated. Equal volumes of dimethyl sulfoxide (DMSO) were used as the negative control. Data were expressed as the mean ± SD (standard deviation) of triplicate independent experiments.