Table 5.

The drugs that target collagen-induced chemoresistance.

Therapeutics Target	Drug	Mechanism	Cancer Type	Status	Reference
collagen	polyethylene glycol (PEG) & glutaraldehyde co-modified fluorinated chitosan (PGFCS)	as a collagen-targeted transepithelial penetration enhancer creating a tumor-targeted adhesive interface to open the transepithelial-delivery barrier at the tumor site	bladder cancer	awaiting further testing	[253]
	losartan	reducing stromal collagen and hyaluronan production to decompress tumor vessels for enhancing drug delivery.	prostate cancer, colorectal cancer, pancreatic cancer, breast cancer, lung cancer, ovarian cancer, endometrial cancer	in clinical application	[254,255,256,257,258,259,260,261]
Collagen type II	Ivosideni	a selective inhibitor of mutant IDH1, which is a gene mutant site of collagen type II	chondrosarcoma	waiting further clinical studies	[262]
ERK1/2	JaZ-30	downregulates phosphorylation of the extracellular signal-regulated ERK1/2	melanoma	waiting further clinical studies	[263]