Table 4.
Frequency of adverse events (AEs) among drug-resistant pulmonary tuberculosis patients (n = 268).
| Grouped AEs | Specific AEs | Frequency of AEs n (%) |
Offending Anti-TB Drug |
|---|---|---|---|
| Gastrointestinal | Nausea | 11 (4.10) | Pyrazinamide, ethionamide |
| Vomiting | 10 (3.73) | Pyrazinamide, ethionamide | |
| Fullness of abdomen | 119 (44.40) | Pyrazinamide, ethionamide | |
| Pain abdomen | 70 (26.12) | Pyrazinamide, ethionamide | |
| Neurological | Peripheral neuropathy | 61 (22.76)) | Linezolid |
| Psychiatric | Psychosis | 37 (13.80) | Cycloserine |
| Depression | 32 (11.94)) | Cycloserine | |
| Skeletal | Arthralgia | 39 (14.55) | Pyrazinamide |
| Ophthalmic | Visual disturbance | 5 (1.86) | Linezolid, ethambutol |
| Endocrinal | Hypothyroidism | 2 (0.74) | Ethionamide |
| Dermatological | Skin discoloration | 21 (7.83) | Clofazimine |
| Cardiological | QTcF prolongation | 31(12.60) | Bedaquiline |
Abbreviations: AEs = adverse events, n = number of cases, % = percent, QTcF = QT interval corrected using Fridericia’s formula.