Table 1.

Summary of the significant correlations between different CD4⁺ Treg/T cell subsets and ICs expression in early and advanced stages.

	PD-1			TIM-3			LAG-3			CTLA-4
	PBMCs	TILs	NILs	PBMCs	TILs	NILs	PBMCs	TILs	NILs	PBMCs	TILs	NILs
FoxP3+	NC	E	E	NC	E/A *	NC	A	E */A	NC	NC	E */A	NC
FoxP3+Helios+	NC	NC	E	NC	E/A *	NC	A	E */A	E	A	E	NC
FoxP3+Helios−	A	A	E	NC	NC	NC	NC	E	NC	NC	E	A
FoxP3−Helios−	NC	E/A *	E	NC	E/A *	NC	NC	E	NC	A	E */A	A

E: early stage, A: advanced stage, NC: no correlation, *: correlation is higher in this stage.