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. 2022 Aug 31;13(3):137. doi: 10.3390/jfb13030137

Figure 12.

Figure 12

Proposed GSH-induced activation mechanism of the theranostic NIR fluorescent anticancer prodrug system. Cleavage of the disulfide bond by thiols such as GSH induces release and activation of the anticancer drug and simultaneously enhances NIR fluorescence. This image has been reproduced with permission from Lui et al. [122] © 2017, American Chemical Society.