Table 2.
Association of TD presence with clinicopathologic characteristics
| Variables | Univariate logistic regression | Multivariate logistic regression | ||||
|---|---|---|---|---|---|---|
| Crude OR | 95% CI | P value | Adjusted OR | 95% CI | P value | |
| Sex | ||||||
| Male | Ref. | |||||
| Female | 0.78 | 0.56–1.08 | 0.142 | |||
| Age (years) | ||||||
| < 58 | Ref. | Ref. | ||||
| ≥ 58 | 1.81 | 1.35–2.46 | < 0.001 | 1.48 | 1.07–2.05 | 0.018 |
| Tumor location | ||||||
| GEJ + Upper 1/3 | Ref. | Ref. | ||||
| Middle 1/3 | 0.67 | 0.47–0.93 | 0.019 | 1.08 | 0.70–1.64 | 0.732 |
| Lower 1/3 | 0.55 | 0.41–0.73 | < 0.001 | 1.07 | 0.74–1.56 | 0.714 |
| Tumor size | ||||||
| < 3.2 cm | Ref. | Ref. | ||||
| ≥ 3.2 cm | 4.04 | 2.88–5.76 | < 0.001 | 1.60 | 1.10–2.35 | 0.016 |
| Histologic grade | ||||||
| Well-moderately | Ref. | |||||
| Poorly | 1.39 | 0.93–2.13 | 0.119 | |||
| T category | ||||||
| T1 | Ref. | Ref. | ||||
| T2 | 11.24 | 2.99–72.96 | 0.002 | 6.34 | 1.65–41.65 | 0.018 |
| T3 | 19.50 | 5.38–124.96 | < 0.001 | 6.96 | 1.82–45.84 | 0.013 |
| T4a | 56.31 | 17.89–341.41 | < 0.001 | 17.78 | 4.86–105.80 | < 0.001 |
| T4b | 208.40 | 54.60–1377.01 | < 0.001 | 51.88 | 12.33–360.701 | < 0.001 |
| N category | ||||||
| N0 | Ref. | Ref. | ||||
| N1 | 5.77 | 3.21–10.83 | < 0.001 | 3.10 | 1.68–5.94 | < 0.001 |
| N2 | 8.82 | 5.05–16.21 | < 0.001 | 3.56 | 1.98–6.73 | < 0.001 |
| N3a | 14.11 | 8.29–25.49 | < 0.001 | 4.99 | 2.83–9.31 | < 0.001 |
| N3b | 16.03 | 8.28–31.89 | < 0.001 | 5.03 | 2.50–10.41 | < 0.001 |
| VELIPI | ||||||
| Negative | Ref. | Ref. | ||||
| Positive | 3.78 | 2.74–5.27 | < 0.001 | 1.13 | 0.79–1.65 | 0.508 |
Abbreviations: CI confidence interval, GEJ gastroesophageal junction, VELIPI vascular emboli, lymphatic, and perineural invasion, TD tumor deposit, OR odds ratio, Ref. reference