Table 5.
Comparison of the performance of the TNM staging system and other revised staging systems for GC
Year | Authors | Description | TNM stage edition | χ2 | AUC | 95% CI | C-index | 95% CI | AIC (f) |
---|---|---|---|---|---|---|---|---|---|
2011 | Wang W. et al. | Presence of TDs (1–2) as pN3 category. Presence of TDs (≥ 3) as M1 category. | 7a | 609.13 | 0.837 | 0.817–0.857 | 0.798 | 0.782–0.814 | 7102.251 |
2012 2017 |
Sun Z. et al. Anup S. et al. |
Presence of TDs as T4a | 7 | 603.16 | 0.834 | 0.814–0.854 | 0.795 | 0.779–0.811 | 7106.225 |
2013 | Lee H.S. et al. | 1 TD as 1 positive LN; revised N category | 7b | 612.53 | 0.832 | 0.812–0.852 | 0.793 | 0.777–0.809 | 7096.855 |
2017 | AJCC | 8th GC’s TNM stage (without TDs) | 8 | 603.77 | 0.834 | 0.814–0.855 | 0.795 | 0.779–0.811 | 7105.614 |
2017 | AJCC | 1 TD as 1 positive LN (8th GC’s TNM N category) | 8 | 628.90 | 0.841 | 0.821–0.861 | 0.800 | 0.784–0.816 | 7080.478 |
2018 | Chen H. et al. | Presence of TDs upstage N stage except for N3b | 8 | 615.94 | 0.839 | 0.819–0.859 | 0.801 | 0.785–0.817 | 7093.440 |
2019 | Liang Y. et al. | Presence of TDs upstage N category as follows: N0→mN2; N1→mN2; N2→mN3a. Others unmentioned remained unchanged. | 8 | 630.49 | 0.841 | 0.821–0.861 | 0.800 | 0.784–0.816 | 7078.888 |
2019 | Tan J. et al. | Presence of TDs as N3 | 7a | 606.83 | 0.836 | 0.816–0.857 | 0.797 | 0.781–0.813 | 7102.546 |
2020 | Gu L. et al. | Presence of TDs upstage TNM stage except for IIIC | 8 | 643.57 | 0.843 | 0.823–0.864 | 0.805 | 0.789–0.821 | 7065.813 |
Abbreviations: AIC Akaike information criterion, AUC area under the curve, CI confidence interval, GC gastric cancer, LNs lymph nodes, TD tumor deposit
Larger χ2, AUC, and C–index values and a smaller AIC value indicate that the system has a better discriminative ability
aWe used the 8th edition of the TNM staging system for GC in our validation, but in these two proposals, N3 was not further divided into N3a or N3b, so we could only use the 7th edition of the TNM staging system for GC
bN category was revised