Binding sites of VNARs to WT SARS-CoV-2 RBD. (A–D) The binding sites of JM-2 (A), JM-5 (B), JM-17 (C), and JM-18 (D) to RBD. The binding residues on RBD are shown in gray. The binding residues on JM-2, JM-5, JM-17, and JM-18 are shown in cyan, yellow, magenta, and orange, respectively.