Figure 2.

Predicted changes in systemic clearance of propofol under normal or reduced CO conditions. (a) Predicted changes in absolute clearance with age. (b) Predicted changes in absolute clearance with age under reduced CO conditions. (c) Relative percentage changes in systemic clearance under reduced CO conditions with age. Open circles represent individual clearance in virtual subjects. (b) Absolute clearance and (c) relative change in clearance of propofol under reduced cardiac output conditions across age groups. For all Figure 2a–c, black open circle and line, red circles and line, blue squares and line, green triangle and line and brown inverted triangles and line represent clearance under normal, 20%, 30%, 40% and 50%-reduced cardiac reduction, respectively.