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. 2022 Sep 17;14(9):1965. doi: 10.3390/pharmaceutics14091965

Figure 5.

Figure 5

The duality of the protein corona. Proteins with a smaller size and lower affinity constitute the so-called “soft” corona. They are loosely attached to the NPs’ surface and relocate from the NPs’ surface rapidly. This promotes the replacement of less abundant proteins with those with higher affinity belonging to the “hard” corona.